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Study of stimuli responsive coating for prevention of bacterial biofilms on contact lenses

Hybrid antibacterial nanoparticles (NPs) of quorum quenching (QQ) enzymes and metals will be generated and deposited on silicone surface via layer-by-layer and ultrasound process. The use of QQ will disrupt the communication of bacterial pathogens and will prevent the infection occurrence, reducing the risk of resistance development.

The student will acquire knowledge of how to prepare and characterize the developed coatings using different techniques available in our lab. He/she will learn to work in a research group, think critically and solve problems in order to complete the scientific mission during the visiting period. Each student will be guided by an expert in the field of chemistry, microbiology, and nano(bio)technology to optimize the research process and maximize her/his learning experience. Furthermore, the applicant will have the opportunity to participate in national/international projects and scientific publications.

Literature research on the current strategies used to control bacterial biofilms and medical device associated infections Literature research in the techniques used to characterize the bulk properties and the added functionalities of the NPs. Literature research on the coating approaches for production of efficient and long-lasting medical devices. Experimental Research: Preparation of antimicrobial NPs using high intensity ultrasound or layer-by-layer self-assembly. NPs characterization by dynamic light scattering, nanoparticle tracking analysis, Z-potential evaluation and Langmuir and Langmuir-Blodgett films. In vitro assessment of the NPs antibacterial activity and their compatibility to human cells. NPs deposition on medical devices via layer-by-layer or ultrasound. Evaluation of the coating antibacterial efficiency against medically relevant bacteria. Stability tests under at use conditions will be also performed. Bachelor or Master Thesis writing Data processing and discussion of the obtained results in a scientific manner.

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