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Nanoenabled hydrogel coatings to control contact lenses associated bacterial infections

Hydrogel containing antibacterial hybrid nanoparticles (NPs) will be generated and deposited on silicone surface via layer-by-layer and ultrasound process.

Objectius The student will learn the normal work in a research laboratory from the idea development until the proof of concept is released and will be guided to develop his/her own critical thinking and problem solving. The student will learn the operational use of several techniques for NPs and hydrogel preparation, functionalization, characterization and coating on medical devices. The applicant will have the chance to be included in a scientific peer-reviewed publication according to his/her contribution.
Tasques a realitzar / Característiques Literature research on the techniques used to characterize the bulk properties and the added functionalities of the developed NPs. Literature research on the composition of the coatings for long stability and sustained release of antimicrobial NPs. Experimental Research: Preparation and functionalization of antimicrobial NPs by means of high intensity ultrasound or layer by layer on template NPs and further inclusion into hydrogels coatings. Preparation of antimicrobial NPs using high intensity ultrasound or layer-by-layer self-assembly. NPs characterization by dynamic light scattering, nanoparticle tracking analysis, Z-potential evaluation and Langmuir and Langmuir-Blodgett films. Development of NPs containing hydrogels on medical devices via layer-by-layer or ultrasound. In vitro assessment of the NPs antibacterial activity and their compatibility to human cells. Evaluation of the coating antibacterial efficiency against medically relevant bacteria. Stability tests under at use conditions will be also performed. Bachelor or Master Thesis writing Data processing and discussion of the obtained results in a scientific manner and their corresponding writing.
Tema Patologia i Farmacologia
Tipus Projecte
TFG/TFM TFG, TFM
Titulació 2012 - MASTER UNIVERSITARI EN OPTOMETRIA I CIÈNCIES DE LA VISIÓ, 2020 - GRAU EN ÒPTICA I OPTOMETRIA, 2022 - MASTER UNIVERSITARI EN OPTOMETRIA I CIÈNCIES DE LA VISIÓ
Paraules clau
Direction
Professor/a tzanko.tzanov
Nom del professor/a Tzanov, Tzanko kaloyanov
Email del professor/a TZANKO.TZANOV@UPC.EDU
Departament 713-EQ
Tipus de codirector/a UPC
Codirector/a kristina.ivanova
Nom del codirector/a Ivanova, Kristina dimitrova
Email del codirector/a KRISTINA.IVANOVA@UPC.EDU
Departament del codirector/a 713-EQ
Other data
Nombre d'estudiants 1
Càrrega de treball TFG 6ECTS = 150h / TFM 12ECTS = 300h
Requisits
Idioma del treball CA, ES, EN
Modality
Modalitat Universitat
Empresa
Options
Possibilitat de beca/finançament no
Confidencial (informatiu) no
Temàtica ambiental no
Ambit de cooperació no
Dates
Data de venciment 09/10/25 23:59
Continguts

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